An osteoporosis drug previously thought to be safe has been linked to doubling the risk of developing cancer of the oesophagus (Source: Nursing in Practice)

In the past 2 decades, 12 new antiepileptic drugs (AED) have been approved by the Food and Drug Administration for the treatment of epilepsy, making the selection process more complex. When choosing an AED several factors are considered including its relative efficacy, tolerability, serious toxicity, ease of use (determined by the pharmacokinetic profile and the drug-drug interaction potential), the presence of comorbid conditions, and cost. Age and gender are also important considerations. The tradition of recognizing a first-choice drug for a certain seizure type or epilepsy syndrome is no longer a practical concept. With so many AED available, depending on several factors, different patients with a similar type of epilepsy may be prescribed entirely different AED. The newer AED have sho...

(Source: AIDS and Behavior)

(Source: AIDS and Behavior)

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(Source: AIDS and Behavior)

(Source: AIDS and Behavior)

(Source: AIDS and Behavior)

(Source: Drugs)

(Source: Drugs)

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Tibotec Pharmaceuticals seeks European Marketing Authorisation for investigational once-daily HIV treatment TMC278 (Source: Pharmacy Europe)

Stroke induces heavy socioeconomic burdens particularly in developing countries. Considering the multisectional discrepancies, strategies of stroke prevention and management adapted for western populations are not always applicable for patients in developing countries. Currently, carotid endarterectomy is the recommended treatment for severe carotid stenosis in the west. Carotid angioplasty and stenting is an alternative treatment only for patients with a high surgery risk. However, in developing countries such as China, where carotid endarterectomy is widely unavailable, Carotid angioplasty and stenting has developed rapidly in recent years and is becoming a choice of treatment for occlusive carotid diseases. (Source: International Journal of Stroke)

Cerebral amyloid angiopathy, a vasculopathy characterised by the deposition of amyloid fibrils in the arteries and arterioles in the cerebral cortex and meninges, has been reported to be associated with intracerebral haemorrhage and cognitive impairment in the elderly. Advances in neuroimaging and validation of the clinical diagnostic criteria aid in making a correct clinical diagnosis. Associations with Alzheimer's disease, asymptomatic microbleeds and white matter changes on neuroimaging have an influence on the clinical treatment for patients with probable cerebral amyloid angiopathy. Reviewing the reports from Asian countries, we found that patients with cerebral amyloid angiopathy have a strong age‐related prevalence and a consistent association with dementia, but a weaker correlati...

Hypertension (HTN) is the most common cause of non‐traumatic ICH, yet echocardiography, which can stage hypertensive heart disease (HHD), is not part of the routine evaluation of patients with ICH. Previous studies have shown that angiotensin converting enzyme inhibitors and angiotensin receptor blockers are associated with regression of left ventricular hypertrophy (LVH) and reversal of myocardial fibrosis. Improvement in these architectural changes in the heart has been shown to improve outcomes and prevent major adverse cardiac events, including stroke. Obtaining echocardiography on ICH patients routinely could help to access the prevalence of HHD and to tailor antihypertensive regimens in this high risk group of patients. Further study is required to determine whether angiotensin dir...

(Source: Journal of Evaluation in Clinical Practice)

A clinical trial of a new drug on patients with advanced (stage IV) pancreatic cancer has been launched (Source: Pharmacy Europe)

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(Source: Reactions)

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