CONCLUSION: There is a high consumption of psychoactive drugs in nursing homes. The association between polypharmacy and depression is evident, and patients with dementia were shown to receive more antipsychotics than other patients. Factors such as age or sex, usually relevant among outpatients, did not present association with psychoactive drug use in nursing home patients. (Source: Revista de Psiquiatria do Rio Grande do Sul)

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CONCLUSION: There is a paucity of articles in the literature focusing on the topic, and no other instruments designed to provide a general overview of substance users (as is the case with the ASI) are available in Brazil. The use of a scale with these characteristics may be useful for the Brazilian public health system, allowing for the early identification of problems and promoting an improvement in the quality of treatment provided to these patients. (Source: Revista de Psiquiatria do Rio Grande do Sul)

One of the most ambitious large-scale projects in Human Genetics has been launched: Epitwin will capture the subtle epigenetic signatures that mark the differences between 5,000 twins on a scale and depth never before attempted, providing key therapeutic targets for the development of drug treatments. The project is a collaboration between TwinsUK, a leading twin research group based at King's College London, and BGI, one of the world's largest genomic organisations headquartered in Shenzhen, China... (Source: Health News from Medical News Today)

How many people do you know who frequently have to change medications because they have a bad reaction -- and need to try another drug? Help may be on the way. A University of Florida researcher has received $9.8 million to help find a way to use genetic... (Source: OrlandoSentinel: Medical Research)

MH.MZ, MDL 100907, and altanserin are structurally similar 4‐benzoyl‐piperidine derivatives and are well accommodated to receptor interaction models. We combined structural elements of different high‐affinity and selective 5‐HT2A (Source: Chemical Biology and Drug Design)

(Source: Chemical Biology and Drug Design)

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It had been reported that cordycepin could activate AMP‐activated protein kinase. One possible mechanism is that cordycepin mediated AMP‐activated protein kinase activation by conversion into cordycepin monophosphate, which acts as an AMP analog to activate AMP‐activated protein kinase. To confirm the aforementioned hypothesis, we investigate the binding of cordycepin monophosphate to AMP‐activated protein kinase using molecular docking. The modeling results indicate that cordycepin monophosphate binds to AMP‐activated protein kinase with high affinity. The hydrogen bonds provide attractive forces between molecules. Our results further identify the key residues contributing to the interaction. Also, the modeling results predict that cordycepin monophosphate and AMP would have sim...

Costimulatory interactions are important regulators of T‐cell activation and, hence, promising therapeutic targets in autoimmune diseases as well as in transplant recipients. Following our recent identification of the first small‐molecule inhibitors of the CD40–CD154 costimulatory protein–protein interaction (J Mol Med (Source: Chemical Biology and Drug Design)

The Greenland and West Antarctic ice caps are melting at half the speed previously predicted, according to analysis of recent satellite data. (Source: ScienceDaily Headlines)

(Source: PharmacoEconomics and Outcomes News)

Drug maker Aurobindo Pharma said it has entered into an agreement with AstraZeneca to supply several solid dosage and sterile products to emerging markets. (Source: The Economic Times Healthcare and Biotech News)

A popular diabetes drug is still being prescribed two months after a safety body recommended its withdrawal amid concerns the drug can increase the risk of heart attacks. (Source: Telegraph Health)

A diabetes drug taken by up to 100,000 patients increases the risk of heart attacks and should be withdrawn on safety grounds, senior doctors say today. (Source: the Mail online | Health)

The Texas Association of Health Plans, which represents health insurers in the Lone Star State, says pharmacy benefit managers, or PBMs, should not be blamed for skyrocketing drug prices. (Source: bizjournals.com Health Care:Health Insurance headlines)

Authors: Traynor K PMID: 20811020 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

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Conclusion Saxagliptin, a DPP-4 inhibitor approved for the treatment of type 2 diabetes, demonstrated safety and efficacy in lowering HbA(1c), FPG, and PPG levels as both monotherapy and in combination with other oral antidiabetic medications. PMID: 20811029 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

Conclusion A pharmacist participating on the ED trauma response team commonly provided dosage recommendations and drug information, facilitated drug administration, and optimized sedation, analgesia, and antimicrobial therapy. PMID: 20811031 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

A POPULAR diabetes drug is still being prescribed, two months after a safety body recommended its withdrawal amid concerns the drug can increase the risk of heart attacks. (Source: Scotsman.com News - Health)

A type two diabetes drug is still being prescribed in the UK two months after it is recommended for withdrawal, Panorama learns. (Source: BBC News | Health | UK Edition)

LONDON (Reuters) - GlaxoSmithKline's diabetes drug Avandia should be pulled from sale because of concerns about heart risks, British drug regulators said on Monday ahead of a special European meeting on the drug's safety. (Source: Reuters: Health)

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